Kazuomi Kario Selected Research

Doxazosin (Cardura)

1/2017	The effect of the bedtime-dosing doxazosin on nocturnal hypoxia-triggered blood pressure surge in a young adult man with severe obstructive sleep apnea syndrome and a history of three recurrent sleep-onset strokes.
1/2013	Clinical implications of the change in glomerular filtration rate with adrenergic blockers in patients with morning hypertension: the Japan morning surge-1 study.
1/2012	Orthostatic hypertension: home blood pressure monitoring for detection and assessment of treatment with doxazosin.
6/2009	Adrenergic blockade improved insulin resistance in patients with morning hypertension: the Japan Morning Surge-1 Study.
7/2008	Effect of doxazosin on the left ventricular structure and function in morning hypertensive patients: the Japan Morning Surge 1 study.
8/2004	Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system.

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Kazuomi Kario Research Topics

Disease

182	Hypertension (High Blood Pressure) 10/2022 - 05/2002
63	Stroke (Strokes) 06/2022 - 01/2002
40	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2002
23	Heart Failure 11/2022 - 07/2008
16	Essential Hypertension 10/2022 - 05/2002
15	Masked Hypertension 01/2021 - 04/2007
15	Atrial Fibrillation 01/2021 - 01/2011
14	Type 2 Diabetes Mellitus (MODY) 01/2021 - 04/2004
14	Diabetes Mellitus 01/2019 - 10/2004
13	Cerebral Hemorrhage 12/2015 - 09/2009
11	Atherosclerosis 04/2022 - 10/2004
11	Chronic Renal Insufficiency 01/2021 - 04/2007
10	Sleep Apnea Syndromes (Sleep Apnea) 01/2022 - 09/2006
10	Myocardial Infarction 01/2021 - 01/2010
10	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 11/2009
10	Inflammation (Inflammations) 01/2016 - 03/2007
9	Hypoxia (Hypoxemia) 01/2021 - 11/2005
9	Ischemic Stroke 01/2020 - 02/2004
9	Cerebral Infarction 06/2012 - 10/2003
8	Hyperuricemia 04/2022 - 11/2019
8	Acute Coronary Syndrome 11/2021 - 01/2005
8	Body Weight (Weight, Body) 01/2021 - 05/2010
8	White Coat Hypertension 01/2020 - 01/2007
8	Obesity 01/2019 - 06/2008
7	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2022 - 10/2004
6	Apnea 01/2022 - 09/2006
6	Obstructive Sleep Apnea 01/2022 - 01/2016
6	Cognitive Dysfunction 11/2018 - 07/2008
6	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2018 - 04/2010
6	Isolated Systolic Hypertension 01/2018 - 01/2015
5	Thrombosis (Thrombus) 01/2021 - 04/2017
5	Tachycardia (Tachyarrhythmias) 01/2020 - 12/2005
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 05/2007
5	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2018 - 07/2002
5	Insulin Resistance 07/2011 - 01/2007
4	COVID-19 10/2022 - 01/2020
4	Carotid Artery Diseases 04/2022 - 01/2012
4	Cardiac Arrhythmias (Arrythmia) 11/2020 - 07/2010
4	Dementia (Dementias) 01/2020 - 02/2010
4	Hyperlipidemias (Hyperlipidemia) 01/2019 - 10/2004
4	Transient Ischemic Attack 01/2019 - 08/2015
4	Albuminuria 11/2013 - 06/2006
3	Coronary Disease (Coronary Heart Disease) 01/2022 - 04/2011
3	Heart Diseases (Heart Disease) 01/2022 - 12/2005
3	Hematoma 04/2021 - 12/2012

Drug/Important Bio-Agent (IBA)

80	Antihypertensive Agents (Antihypertensives)IBA 01/2022 - 01/2002
21	SaltsIBA 06/2022 - 11/2008
17	Biomarkers (Surrogate Marker)IBA 12/2021 - 01/2007
16	4- (2- (4- hydroxybenzyl)- phenoxy)- N- methylbutylamineIBA 01/2022 - 05/2015
14	Pharmaceutical PreparationsIBA 08/2022 - 04/2011
12	olmesartanIBA 01/2022 - 04/2011
12	salicylhydroxamic acid (SHAM)IBA 01/2022 - 01/2016
12	Angiotensin Receptor AntagonistsIBA 01/2021 - 04/2009
12	Tissue Plasminogen Activator (Alteplase)FDA Link 10/2013 - 06/2008
12	C-Reactive ProteinIBA 06/2013 - 03/2007
11	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2022 - 01/2008
11	Glucose (Dextrose)FDA LinkGeneric 11/2018 - 01/2007
11	Amlodipine (Norvasc)FDA LinkGeneric 01/2018 - 05/2002
10	Neprilysin (Neutral Endopeptidase)IBA 01/2022 - 02/2014
10	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 02/2014
10	DiureticsIBA 01/2021 - 06/2010
9	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2022 - 02/2014
8	Uric Acid (Urate)IBA 01/2022 - 03/2017
8	Oxygen (Dioxygen)IBA 01/2022 - 11/2005
8	AnticoagulantsIBA 01/2021 - 01/2012
8	cilnidipineIBA 01/2021 - 12/2005
8	Warfarin (Coumadin)FDA LinkGeneric 01/2019 - 01/2012
7	pro-brain natriuretic peptide (1-76)IBA 11/2022 - 05/2014
7	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2021 - 01/2016
7	Valsartan (Vals)FDA Link 01/2021 - 05/2007
7	AlbuminsIBA 01/2021 - 06/2008
7	CalciumIBA 01/2021 - 05/2002
7	omega-Chloroacetophenone (Mace)IBA 11/2020 - 01/2012
6	Febuxostat FDA Link 04/2022 - 01/2020
6	CholesterolIBA 01/2022 - 06/2006
6	CreatinineIBA 01/2021 - 08/2010
6	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2020 - 05/2002
6	Doxazosin (Cardura)FDA LinkGeneric 01/2017 - 08/2004
6	Indicators and Reagents (Reagents)IBA 01/2016 - 10/2003
5	SodiumIBA 01/2022 - 08/2008
5	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2020 - 05/2002
5	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2016 - 06/2002
5	Hemostatics (Antihemorrhagics)IBA 04/2015 - 10/2004
5	azelnidipineIBA 03/2013 - 06/2007
4	AldosteroneIBA 08/2022 - 01/2007
4	antineoplaston A10 (A 10)IBA 06/2022 - 12/2003
4	N-Type Calcium Channels (N-Type Calcium Channel)IBA 01/2021 - 12/2005
4	candesartanIBA 06/2014 - 10/2002
4	Adrenergic Agents (Adrenergic Drugs)IBA 12/2013 - 07/2002
4	Insulin (Novolin)FDA Link 06/2010 - 06/2006
3	Angiotensin IIIBA 01/2022 - 10/2002
3	Troponin T (Troponin T1)IBA 12/2021 - 05/2013

Therapy/Procedure

63	Therapeutics 10/2022 - 09/2002
34	Denervation 01/2022 - 06/2013
10	Catheters 01/2022 - 01/2016
10	Percutaneous Coronary Intervention 09/2021 - 01/2012
6	Drug Therapy (Chemotherapy) 01/2022 - 09/2011
6	Stents 04/2021 - 01/2012
4	Continuous Positive Airway Pressure 01/2022 - 07/2014
3	Blood Pressure Monitors 01/2021 - 12/2016